In this paper,aiming at the problems appeared in the research-based teaching of undergraduate specialized courses and combining with the characteristics of“Introduction to Biomaterials” course,“Four-in-one” teaching reform is explored and carried out with the guidance of classroom teaching combining basic knowledge with scientific research,the core of interactive thematic discussion,the assistance of self-directed learning,network platform and group discussion and summary,and the support of process performance and thesis achievement.This teaching method not only lays a solid foundation of students' specialty basic knowledge,but also guides students to follow the academic frontier and think initiatively,which improves their ability to analyze and solve problems with professional knowledge.