Abstract: The self-reform of the Communist Party of China (CPC) is not to negate the history of the party or change its purpose, but to eliminate all adverse factors for its development and construction to ensure the party can constantly stay true to its original mission, ideals and faith and always “share the same breath and fate” with the Chinese people while retaining its advanced and pure quality. The CPC’s self-reform reflects the idea of people’s centeredness and is the newest achievement in its exploration into the laws of the rise and fall of civilizations over more than 100 years. In addition, it is also the fundamental guarantee for comprehensively building China into an all-round socialist country and advancing the great rejuvenation of the Chinese nation, as well as the striking signature that separate the CPC from other parties. Carrying with it combined concepts of subjective elements and practical orientation, the self-reform of CPC reflects the “combined efforts” of CPC members in tackling the problem of historical cycles. The self-reform of CPC is a high-level, high-quality reform that constantly advances its self-purification, self-perfection, self-innovation and self-improvement competence construction, relentless rectification of “four kinds of bad conducts” and integrated progress in no nerve, no capability and no desire of corruption with strictly disciplined party governance. Making anti-corruption as the long-term and imperative major political task is the practical requirement in the self-reform of CPC.