Abstract: The reform and opening-up is a magnificent social revolution in the history of the development of socialism with Chinese characteristics, and it is also the source of strength for promoting Chinese modernization and achieving the great rejuvenation of the Chinese nation. It is of great significance to effectively present the stories of reform and opening-up in the teaching of the course “An Introduction to Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era”. It is crucial to closely focus on the essence of the spirit of reform and opening-up, which includes “emancipating the mind, seeking truth from facts, keeping pace with the times, and being realistic and pragmatic”, adhere to the integration of theory and practice, the interweaving of history and reality, the juxtaposition of emotions and facts, and the synergy between online and offline platforms. By delving deep into the rich connotations of the narrative of reform and opening up, depicting the challenging journey of exploration during this period, igniting the vitality of the spirit of reform and innovation, showcasing the diverse colors of the canvas of reform and opening up, we can encourage college students to delve deeply into the theory and practice of comprehensively deepening reform and opening-up, inspire them to engage in positive reflections on society and life, and cultivate a new generation of talents who can shoulder the great responsibility of national rejuvenation.