Abstract: After a hundred years of continuous struggle, the realization of the great rejuvenation of the Chinese nation has finally entered an irreversible historical process in the new era, which means that no force or difficulty can stop the continuation of this historical process. On the new journey in the new era, the national rejuvenation strategy and the once-in-a-century changes taking place in the world interact with each other in the same space and time, and the situation at home and abroad has become more complex and volatile, and the comprehensive promotion of the great rejuvenation of the Chinese nation through Chinese modernization faces new strategic opportunities, ushers in new strategic tasks, enters a new strategic stage, realizes new strategic requirements, and is in a new strategic environment. These “five new” constitute the main aspects of the epochal situation in which national modernization and rejuvenation are moving in the same direction; by accurately understanding these “five new”, the Party and the country will be able to target their development on the new journey, and the great cause of national rejuvenation will achieve new victories continuously.