Abstract: The organic unity of following the laws of social and historical development and giving full play to subjective initiative is the essence of the scientific connotation of the spirit of historical initiative. It is embodied in the scientific spirit of following the laws of social and historical development, the practical spirit of accurately grasping the opportunities of historical development, and the missionary spirit of proactively taking up the responsibility of national rejuvenation. It is a concentrated manifestation of the historical initiative of the CPC in its century-long struggle, and an important spiritual code for the continuous new victories of revolution, construction and reform. In the new era of comprehensively building a socialist modernized country, facing new historical conditions such as the accelerated evolution of the world pattern, the rise of new scientific and technological revolution, and the climbing of high-quality development, a profound understanding, scientific grasp, and full play to the historical initiative spirit are important ideological conditions to ensure that the Party and the country always stay at the forefront of the times, and to promote the construction of the Party, the construction of a strong country, and the rejuvenation of the nation.