Abstract: Facing the rapid growth of society in the information age, this paper carries out the cultivating practice of highly qualified application-oriented innovative talents who are not only proficient in mechanical design and manufacturing, but also good at intelligent system design and application. It aims to construct a paradigm of curriculum system that combines large class training and individual growth in mechanical engineering. The connotative construction of mechanical engineering will be integrated with information characteristics, which can upgrade and transform the traditional mechanical design and manufacturing and automation majors, and build new interdisciplinary robotics engineering. In this study, we integrate information characteristics and practical innovation into the compulsory general education, design a four-in-one (i.e., “learning-experience-nurturing-innovation”) general elective course system, and build a professional foundation of “machinery + information” interdisciplinary intersection. We also innovate a hierarchical and progressive whole-project professional course system, and form a paradigm of “comprehensive development−solid foundation−multi-path selection” course system. The organization and implementation of the curriculum system paradigm can innovate the “major course” project-led integration of non-technical ability training, the “major practice platform” real-scene multi-path training, and the “golden course”-led classroom teaching method reform, and provide effective guarantee for the realization of the curriculum system paradigm with satisfactory training results. Also, our study provides theoretical and practical experiences for other universities to advance the reform of related majors and talents training.