Abstract: To deeply study and understand the great significance of Xi Jinping’s reply to the senior professors of University of Science and Technology Beijing is to learn the importance to the construction and development of University of Science and Technology Beijing, the development of higher education and the promotion of high-level scientific and technological self-reliance of colleges and universities. It is necessary to closely combine the study and publicity of the important reply spirit with the study and implementation of the Xi Jinping’s important exposition on education. Adhere to the guidance of Party building, internalize the political and organizational advantages of the party’s leadership into the political consciousness, ideological consciousness and action consciousness of learning and implementing the important reply spirit, and effectively transform the reply spirit into a magnificent driving force for forging ahead on a new journey, so as to provide a strong guarantee for building the steel backbone of a strong scientific and technological country and a strong manufacturing power.