Abstract: The clinical trial is an indispensable hnk in the new drug research and development (R&D), in which subjects are extremely vulnerable, and the human subject protection is an ethical issue in the new drug R&D process. In this paper, considering the ethics of care as a solution to this problem and the "relation self" as its ontological basis, starting from the women's "common experience", we explore the ethical basis for protection of the subjects. We conclude that "concerning for others" is the inherent requirement of the protection, and "emotional empathy " is the subject practice demands of the protection. It is of great value for human rights protection in a broad sense.