Abstract: Realism is the most influential school of contemporary global governance.It still dominates the governance practices of various countries in the context of the epidemic of NCP.The realist view of global governance is rooted in the ideological tradition of political realism,which has been passed down through traditional realism to neorealism.It is the orthodoxy of global governance.Based on the view of evil nature, reasonal actors and international anarchy, realism takes a pessimistic and cautious approach to global governance, highlighting the dominance of state, and endowing power politics with decisive position.Then realism created a world of hostilities and conflicts.It is helpful to analyze the historical evolution and developmental logic of realism for understanding the global epidemic governance.