Abstract: With the development of social economy and the progress of science technology, the demand of apphed talents in instrument science and technology is increasing. The experimental teaching in the instrument science and technology is one of the most important curricula in the college life, and it is the main way to cultivate applied talents. In the past ten years, a series of exploration and research were taken by the universities to improve the experimental teaching system. In this paper, some reform ideas are put forward and the experimental teaching system with Chinese characteristics is explored by comparing the current situation of experimental teaching in universities at home and abroad, which can cultivate students' innovative consciousness and scientific literacy.