Abstract: With the increase of population, the development of science and technology and the frequency of international trade, it is a historical inevitability that transgenosis technology in genetic engineering came into being and began to develop. However, there are some uncertain influence on food and ecological environment due to the transgenosis, thus arousing people's reflection on its safety. In China, in terms of the legislation on the safety of transgenosis engineering, there are some drawbacks such as lag, uncertainty of the application scope, poor workability, and inefficiency of the the safety precaution. It is essential to establish perfect laws which mainly include the regulation of license of transgenosis engineering, the regulation of expression, the regulation of safety estimation, the regulation of inspection, the regulation of standard and the regulation of transgenosis patent.