Abstract: Karl Marx first explained the theory of Estranged Labor comprehensively in the Economic and Philosophical Manuscript. In the German Ideology, Marx explained the alienation further from practice and the life conditions in reality to develop the theory of Estranged Labor. The book On Capital analyzed specifically the emergence of estranged labor and the alienation from its production, circulation and distribution aspects, which is the development of the theory of Estranged Labor deeply. Marxist Feminists refer to the theory of Estranged Labor of Karl Marx, and use it in the fields of family and private activity to put forward the theory of gender alienation creatively. It can be said that the theory of gender alienation is the newdevelopment of the theory of Estranged Labor in the newphase of the capitalism society. Marxist Feminists expand the alienation to the fields of housework, the relationship between men and women, and mentality. In the meantime, Marxist Feminists analyze the social status of women, and raise the ways to realize the liberation of women by eliminating the alienation.