Abstract: In the post Cold War era, neo-eonservatives obstinately adopted a hostile attitude toward China, resolutely sticked to the Cold War mentality, stressed on ideological divergence, took China as the next strategic emphatically antagonist and potential threat in stead of USSR and maintained tough policies to China. Being influenced by the Neo-conservatism, the US government has taken a measure of anti-communism to contain the emergency of China; emphasized on ideology to promote democracy and focused on the human rights to interfere China's internal affairs. Such strategies severely hinder the sound development of Sino-U. S. Relations. Fully analysing American Neo-eonservatism is significant to study Sino-U. S. Relations.